In the article discussed the fungal plant diseases detected in cotton crops in our country and biological control measures against them. Studies have shown that the main pathogens of root rot in cotton are microscopic fungi Rhizoctonia solani, Thielariopsis basicola, Fuzarium spp, Pythium spp. are included.
According to the study, in terms of damage caused by seedling diseases, on average for the last 3 years, 22.6% of the cotton crop that died the highest of all diseases was caused by seedling diseases. In the second place, verticillosis mortality was 19.23%, cos sack rot was 19.1% and the lowest fusarium wilt mortality was 7.48%.
Based on the data obtained, it was concluded that the development of root rot diseases in cotton is caused by low soil and air temperatures, deeper sowing of seeds than recommended, hardening, excess moisture, poor loosening of the soil, contamination with pathogenic fungi.
Врождённые пороки развития являются одной из основных причин перинатальной и ранней детской смертности, вызывая серьёзные медикосоциальные проблемы в обществе. Врождённые пороки развития встречаются у 5% младенцев, но их вклад в структуру детской смертности достигает 20% и выше.
Obstetric hemorrhages, despite the global measures introduced to prevent them, still represent a real threat to the maternal health and life, and require a search for more effective measures for their prevention and treatment. The list of references which formed the basis for the present review will allow the reader to determine the vector of searching for modern information on obstetric hemorrhages, to compare the outcomes of labor with postpartum hemorrhage in different countries, and to understand the prognostically significant risk factors.
Улучшение состояния здоровья населения за счет повышения доступности, расширения структуры медицинских учреждений, оптимизации оказания медицинской помощи является главной целью развития системы здравоохранения на современном этапе. Проводимые реформы Государственной политики здравоохранения по охране здоровья женщин и детей привели к видимым сдвигам по нескольким ключевым глобальным индикаторам в секторе здравоохранения, и в частности в сфере репродуктивного здоровья В достижении этих показателей значимое место занимает деятельность перинатальных центров, в частности Республиканского перинатального центра (РПЦ) и его филиалов (ПЦ).
Несмотря на достижения в профилактике и лечении послеродовые кровотечения остаются важной проблемой в акушерстве. Послеродовые кровотечения являются одной из основных причин материнской смертности.
The problem of the development of polyhydramnios is relevant in connection with the complications of pregnancy and childbirth, both for the mother and for the fetus. One of the most dangerous complications is hypotonic bleeding in the postpartum period, which leads to an increase in maternal morbidity and mortality. Among the causes of bleeding, polyhydramnios, the frequency of which reaches 1–8% of the total pool of pregnant women, occupies one of the leading positions. The aim of the study was to study the features of the clinic and the morphological structure of the uterine wall in polyhydramnios of varying severity. All this dictates the need to improve ways to prevent hypotonic postpartum bleeding in women with polyhydramnios.
The purpose of the study is to determine the significance of genetic factors in the development of chronic nephritic syndrome in children and to clarify the features of the clinical course
The оbject of research were 129 children aged 4-15 years who were treated for chronic nephritis in the nephrology department of the Samarkand Regional Multidisciplinary Paediatric Medical Centre.
The scientific novelty of the study is as follows:it has been established that the severity of chronic nephritic syndrome in children is associated with clinical manifestations (gradual development, dyspepsia, abdominal pain) and an increase in the amount of Cystatin C in the blood;for the first time, it was revealed that the development of sclerotic lesions due to increased proliferation in patients with the presence of the MMP-9 (A-8202G) rs 11697325 genotypes in chronic nephritic syndrome leads to a worsening of the clinical course of the disease; established early diagnostic marker MMP-9 (A-8202G) rs 11697325 and its tissue inhibitor TIMP-2 (C536T) rs 11551797 in chronic nephritic syndrome in children in the diagnosis of the disease; for the first time, the prognostic value of the alleles of the MMP-9 (A-8202G) rs 11697325 genes and the homozygous G/G genotype in determining the risk of developing the disease in children with chronic nephritic syndrome has been proven.
Implementation of the research results. Based on scientific results of evaluation of the role of polymorphic genes of matrix metalloproteinase and its tissue inhibitors in chronic nephritic syndrome in children: methodological recommendation “The role of polymorphic genes of matrix metalloproteinase and its genetic inhibitors in the development of chronic nephritic syndrome in children” was developed and approved (reference of the Ministry of Health of the Republic of Uzbekistan No. 8n-r / 554 of 30.02.2022).
This methodological recommendation made it possible to predict the development of chronic nephritic syndrome in children and improve preventive measures; approved and developed on the basis of scientific results of research on early diagnosis and prognosis of chronic nephritic syndrome “Dynamics of clinical and laboratory parameters in nephritic syndrome in children”, (reference of the Ministry of Health of the Republic of Uzbekistan No. 8n-r / 555 of 30.02.2022).
This methodological recommendation made it possible to optimize the diagnosis and treatment tactics for various forms of nephritic syndrome in children;
The results obtained were implemented in the practice of health care, in particular, in the Republican Children's National Medical Center, in the 1st clinic of the Samarkand State Medical University, in the Samarkand Regional Children's Multidisciplinary Medical Center (conclusion No. 8 n-r/324 of 21.06.2022 of the Ministry of Health of Uzbekistan).
The application of the obtained results to practice has made it possible to reduce the frequency of recurrence of the disease in children, prevent complications of the disease, improve the quality of life of patients, diagnose and prevent the disease.
The structure and scope of the dissertation. The dissertation consists of an introduction, 4 chapters, conclusions, practical recommendations. The volume of the dissertation is 120 pages.